The ability of salinomycin to kill both cancer stem cells and therapy-resistant cancer cells (persister) may define the compound as a novel and an effective anticancer drug. It has been also shown that salinomycin and its derivatives exhibit potent antiproliferative activity against the drug-resistant cancer cell lines.

Salinomycin, a polyether antibiotic produced by Streptomyces albus, is widely used in animal husbandry as an anticoccidial drug and growth promoter. Situated within the salinomycin biosynthetic gene cluster, slnR encodes a LAL-family transcriptional regulator. The role of slnR in salinomycin production in S. albus was investigated by gene deletion, complementation, and overexpression. Gene

Catalog # 3637. Datasheet / COA / SDS. Antibiotics Small Molecule. Discontinued Product. 3637 has been discontinued. View all Salinomycin is a polyether antibiotic isolated from Streptomyces spp. and a monovalent ionophore for alkali ions with relative K+ selectivity, able thus to interfere Learn more about Salinomycin and get the best prices in the life science marketplace at AG Scientific, Inc. We have over 20 years of experience with Accordingly, we investigated whether salinomycin, a monocarboxylic ionophore, could induce apoptosis in aggressive breast cancer cells or not, as well as its 24 Aug 2019 A few clinical case reports have documented effectiveness of salinomycin in therapy-resistant cancer patients, e.g., a patient with metastatic 25 May 2020 Salinomycin-loaded PLA nanoparticles: drug quantification by GPC and wave voltammetry and biological studies on osteosarcoma cancer stem Unfortunately Salinomycin sodium salt (Cat.

Salinomycin

Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods Primary tumor-initiating Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs). However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1 Salinomycin, a commercially significant coccidiostat isolated from , has been synthesised from three principal fragments. Key steps include (a) the use of η-allylmolybdenum cationic complexes 21a,b for the stereoselective construction of two contiguous stereogenic centres in fragment 5a; (b) the electrophilic cycli Salinomycin induces massive apoptosis in the multidrug-, radiation- and apoptosis-resistant human cancer cells.

25 May 2020 Salinomycin-loaded PLA nanoparticles: drug quantification by GPC and wave voltammetry and biological studies on osteosarcoma cancer stem

Discontinued Product. 3637 has been discontinued. View all Salinomycin is a polyether antibiotic isolated from Streptomyces spp. and a monovalent ionophore for alkali ions with relative K+ selectivity, able thus to interfere Learn more about Salinomycin and get the best prices in the life science marketplace at AG Scientific, Inc. We have over 20 years of experience with Accordingly, we investigated whether salinomycin, a monocarboxylic ionophore, could induce apoptosis in aggressive breast cancer cells or not, as well as its 24 Aug 2019 A few clinical case reports have documented effectiveness of salinomycin in therapy-resistant cancer patients, e.g., a patient with metastatic 25 May 2020 Salinomycin-loaded PLA nanoparticles: drug quantification by GPC and wave voltammetry and biological studies on osteosarcoma cancer stem Unfortunately Salinomycin sodium salt (Cat.

Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, or other pathways.

Using this Salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. It has also been demonstrated as a positive ionotropic and chronotropic agent that increased cardiac output, left ventricular systolic pressure, heart rate, mean arterial pressure, coronary artery vasodilatation and blood flow, and plasma 2019-02-14 · Objectives Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far. Thus, here we aimed to investigate the activity of salinomycin against tumor initiating cells isolated from patients with colorectal cancer. Methods Primary tumor-initiating Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs). However, the antitumor mechanism of salinomycin is unclear.

Similar Structures. Structure for Salinomycin (DB11544) Salinomycin(Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic drug.; IC50 Value:; Target: Antibacterial; Anticancer; Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, The salinomycin come in different sizes, packaging styles, and designs to address the various concerns of individuals and groups. If you are a farmer with many animals, you will find salinomycin in large packages to provide you with optimal transportation convenience. Visit ChemicalBook To find more Salinomycin(53003-10-4) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes.
Overkalixmal

At last,Salinomycin(53003 … White to slightly yellow lyophilizated powder. Purity by HPLC: ≥98% ; refer to CoA for more data 2019-11-25 Salinomycin Sodium (syn: Coxistal, Coxistac) is the sodium salt of Salinomycin, a carboxylic polyether ionophore isolated from Streptomyces albus that has been widely used as an agricultural antibiotic to prevent coccidiosis in poultry.

2.1 Pre-clinical.
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Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt (Salinomycin sodium) acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem …

Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Salinomycin (71; R = H), obtained by culturing a strain of Streptomyces albus 〈72JAP(K)7225392〉, and narasin (71; R = Me), 4-(S)-methylsalinomycin, the main component of a polyether complex produced by Streptomyces aurofaciens 〈78JAN1〉 are now used to prevent coccidiosis, particularly in broiler chickens. Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Millipore Substance identity Substance identity. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases.

Salinomycin sodium (SAL‐Na) is active against certain Gram‐positive bacteria, while Gram‐negative species are resistant. SAL‐Na at the proposed concentration is unlikely to increase shedding of Salmonella, Escherichia coli and Campylobacter and or induce resistance and cross‐resistance to antimicrobials important in human and animal

Poult Sci. 1986 Oct;65(10):1955-9.PubMed:3797377 Salinomycin is widely used in animal husbandry as a food additive due to its antibacterial and anticoccidial activities.

It came on the center stage in cancer drug studies after the revelation of its ability to specifically kill cancer stem cells (CSCs) (Gupta et al., 2009).